LncRNA polymorphisms and lung cancer risk.
Esmat AbdiSaeid Latifi-NavidAlireza PanahiHamid Latifi-NavidPublished in: Personalized medicine (2023)
Lung cancer (LC) imposes a significant burden, and is associated with high mortality and morbidity among malignant tumors. Aberrant expression of particular lncRNAs is closely linked to LC. LncRNA polymorphisms cause abnormal expression levels and/or structural dysfunction. They can affect the progression of cancer, survival, response to chemotherapy and recurrence rates in cancer patients. The present article provides a comprehensive overview of the effect of lncRNA genetic polymorphisms on LC. It is proposed that lncRNA-related variants can be used to predict cancer risk and therapeutic outcomes. More large-scale trials on diverse ethnic groups are required to validate the results, thus personalizing LC therapy based on lncRNA genotypes.
Keyphrases
- long non coding rna
- poor prognosis
- simultaneous determination
- long noncoding rna
- mass spectrometry
- binding protein
- squamous cell carcinoma
- papillary thyroid
- type diabetes
- bone marrow
- radiation therapy
- coronary artery disease
- young adults
- copy number
- high resolution
- mesenchymal stem cells
- genome wide
- glycemic control
- squamous cell
- network analysis
- gas chromatography