Maternal resistin predisposes offspring to hypothalamic inflammation and body weight gain.
Ghislaine PoizatCoralie AlexandreSarah Al RifaiLaure RiffaultDelphine CrepinYacir BenomarMohammed TaouisPublished in: PloS one (2019)
Resistin promotes hypothalamic neuroinflammation and insulin resistance through Toll like receptor 4 (TLR4), this hormone is thought to be a link between obesity and insulin-resistance. Indeed, resistin plasma levels are higher in obese and insulin resistant subjects. However, the impact of maternal resistin on the predisposition of offspring to hypothalamic neuroinflammation is unknown. Here, female mice were treated with resistin during gestation/lactation periods, then hypothalamic neuroinflammation was investigated in male offspring at p28 and p90. At p28, resistin increased the expression of inflammation markers (IL6, TNFα and NFκB) and TLR4 in the hypothalamus and decreased both hypothalamic insulin and leptin receptors' expression. The hypothalamic up-regulation IL6, TNFα and TLR4 was sustained until p90 promoting most likely hypothalamic inflammation. Maternal resistin also increased IL6 and TNFα in the adipose tissue of offspring at p90 associated with a higher body weight gain. In contrast, liver and muscle were not affected. These findings reveal that the augmentation of maternal resistin during gestation and lactation promotes hypothalamic and adipose tissue inflammation of offspring as evidenced by sustained increase of inflammation markers from weaning to adulthood. Thus, maternal resistin programs offspring hypothalamic and adipose tissue inflammation predisposing then offspring to body weight gain.
Keyphrases
- weight gain
- birth weight
- high fat diet
- adipose tissue
- insulin resistance
- toll like receptor
- oxidative stress
- gestational age
- body mass index
- type diabetes
- high fat diet induced
- weight loss
- inflammatory response
- metabolic syndrome
- nuclear factor
- lps induced
- rheumatoid arthritis
- immune response
- poor prognosis
- skeletal muscle
- lipopolysaccharide induced
- traumatic brain injury
- polycystic ovary syndrome
- pregnancy outcomes
- signaling pathway
- preterm infants
- preterm birth
- pregnant women
- public health
- gene expression
- blood brain barrier
- single cell
- magnetic resonance
- subarachnoid hemorrhage
- glycemic control
- long non coding rna
- acute respiratory distress syndrome
- dna methylation
- high resolution