Characterization of esophageal motor activity, gastroesophageal reflux, and evaluation of prokinetic effectiveness in mechanically ventilated critically ill patients: a high-resolution impedance manometry study.

Karel BaliharJan KotyzaLucie ZdrhovaJana KozeluhovaMichal Krcma Martin Matejovic

Published in: Critical care (London, England) (2021)

All critically ill patients had major esophageal motility abnormalities, and motility patterns varied according to gastric emptying status. Well-preserved gastric emptying and maintained esophagogastric barrier functions did not eliminate reflux. Metoclopramide failed to reduce the number of reflux episodes regardless of gastric emptying status. Trial registration ISRCTN, ISRCTN14399966. Registered 3.9.2020, retrospectively registered. https://www.isrctn.com/ISRCTN14399966 .

Keyphrases

high resolution
biofilm formation
randomized controlled trial
intensive care unit
systematic review
study protocol
acute respiratory distress syndrome
mass spectrometry
phase iii
liquid chromatography