Our study indicates that the low expression of SQLE employs adaptive survival through regulating the balance of apoptosis and ferroptosis resistance. In future, the combinational therapy of targeting SQLE and ferroptosis could be a promising approach in treating LUSC.
Keyphrases
- oxidative stress
- cell death
- squamous cell carcinoma
- poor prognosis
- cell cycle arrest
- endoplasmic reticulum stress
- dna damage
- hydrogen peroxide
- ischemia reperfusion injury
- induced apoptosis
- current status
- cancer therapy
- nitric oxide
- mesenchymal stem cells
- bone marrow
- radiation therapy
- free survival
- lymph node metastasis
- cell proliferation
- heat shock