Diagnostic and Prognostic Value of miRNAs after Coronary Artery Bypass Grafting: A Review.
Ewelina BlazejowskaTomasz Kamil UrbanowiczAleksandra GaseckaAnna Olasinska-WisniewskaMiłosz Jarosław JaguszewskiRadosław TargońskiAgnieszka SzarpakKrzysztof Jerzy FilipiakBartlomiej PerekMarek JemielityPublished in: Biology (2021)
MiRNAs are noncoding, 21-24 nucleotide-long RNA particles that control over 60% of genes. MiRNAs affect gene expression through binding to the 3'-untranslated region of messenger RNA (mRNA), thus inhibiting mRNA translation or inducing mRNA degradation. MiRNAs have been associated with various cardiovascular diseases, including heart failure, hypertension, left ventricular hypertrophy, or ischemic heart disease. In addition, miRNA expression alters during coronary artery bypass grafting (CABG) surgery, which could be used to predict perioperative outcomes. CABG is an operation in which complex coronary arteries stenosis is treated by bypassing atherosclerotic lesions with venous or arterial grafts. Despite a very low perioperative mortality rate and excellent long-term survival, CABG is associated with postoperative complications, including reperfusion injury, graft failure, atrial fibrillation and perioperative myocardial infarction. So far, no reliable diagnostic and prognostic tools to predict prognosis after CABG have been developed. Changes in the perioperative miRNA expression levels could improve the diagnosis of post-CABG myocardial infarction and atrial fibrillation and could be used to stratify risk after CABG. Herein, we describe the expression changes of different subtypes of miRNAs during CABG and review the diagnostic and prognostic utility of miRNAs in patients undergoing CABG.
Keyphrases
- coronary artery bypass grafting
- percutaneous coronary intervention
- coronary artery disease
- heart failure
- patients undergoing
- left ventricular
- atrial fibrillation
- acute myocardial infarction
- poor prognosis
- coronary artery bypass
- gene expression
- binding protein
- cardiac surgery
- cardiovascular disease
- cardiovascular events
- left atrial
- blood pressure
- dna methylation
- coronary artery
- minimally invasive
- cardiac resynchronization therapy
- adipose tissue
- left atrial appendage
- signaling pathway
- metabolic syndrome
- mitral valve
- hypertrophic cardiomyopathy
- type diabetes
- acute kidney injury
- venous thromboembolism
- skeletal muscle
- risk factors
- surgical site infection
- aortic valve
- weight loss
- genome wide identification