F-18 FDG PET brain imaging in symptomatic arthroprosthetic cobaltism.
Robert L BridgesChristina S ChoMarc R BeckBradford D GessnerStephen S TowerPublished in: European journal of nuclear medicine and molecular imaging (2019)
All scanned patients had regions of significant hypometabolism. Neurological toxicity from elevated systemic cobalt levels following arthroprosthetic joint replacement has a pattern of regional susceptibility similar to heavy metals and solvents, differing from classical dementias and may occur at blood and urine cobalt levels as low as 0.4 mcg/L and 1 mcg/L, respectively. Presently accepted thresholds for cobalt exposure and monitoring may need revision. Quantitative F-18 FDG PET brain imaging may aid in the decision process for treatment options and timing of possible medical versus surgical intervention.
Keyphrases
- pet ct
- positron emission tomography
- pet imaging
- high resolution
- heavy metals
- computed tomography
- end stage renal disease
- resting state
- newly diagnosed
- reduced graphene oxide
- white matter
- randomized controlled trial
- ejection fraction
- healthcare
- total knee arthroplasty
- cerebral ischemia
- chronic kidney disease
- functional connectivity
- carbon nanotubes
- metal organic framework
- prognostic factors
- risk assessment
- multiple sclerosis
- ionic liquid
- brain injury
- fluorescence imaging
- health risk