Human amyloid-β enriched extracts: evaluation of in vitro and in vivo internalization and molecular characterization.
Cristina M Pedrero-PrietoAlicia Flores-CuadradoDaniel Saiz-SánchezIsabel Úbeda-BañónJavier Frontiñán-RubioFrancisco J AlcaínLourdes Mateos-HernándezJosé de la FuenteMario Durán-PradoMargarita VillarAlino Martínez-MarcosJuan Ramón PeinadoPublished in: Alzheimer's research & therapy (2019)
Identification and characterization of the unique features of these extracts, in terms of amyloid-β enrichment, identification of the components, in vitro and in vivo cell internalization, and tissue distribution, constitute the best initial tool to further investigate the seeding and transmissibility proposed in the prion-like hypothesis of Alzheimer's disease.