A Microenvironment-Related Nine-Gene Signature May Predict Survival in Mycosis Fungoides Patients at Diagnosis.
Silvia Alberti ViolettiMaria Rosaria SapienzaMarcello Del CorvoFederica MelleGiovanna MottaLuigia VenegoniLorenzo CerroniCarlo CotaAlessandro PileriEmilio BertiStefano A PileriPublished in: Cells (2023)
Mycosis fungoides (MF) is the most common cutaneous lymphoma characterized by an indolent course. Prognosis is stage-based but this approach does not reflect the different outcomes within stages. Considering that tumor microenvironment is known to be involved in MF pathogenesis and progression, we decided to investigate 99 MF cases by using the PanCancer Immune Profiling Panel. We identified and validated a signature of 9 genes able to predict MF survival and distinguish a high-risk group with a worse outcome from a low-risk group of cases with a better outcome. At the molecular level, low-risk vs. high-risk cases reported a global upregulation of immune genes, enriched in cytokines, and a higher density of dendritic cells and mast cells, possibly associated with a more favorable clinical course.
Keyphrases
- dendritic cells
- genome wide
- end stage renal disease
- genome wide identification
- ejection fraction
- chronic kidney disease
- newly diagnosed
- stem cells
- cell proliferation
- prognostic factors
- poor prognosis
- genome wide analysis
- bioinformatics analysis
- single cell
- adipose tissue
- copy number
- signaling pathway
- gene expression
- metabolic syndrome
- transcription factor
- hodgkin lymphoma