Extracellular vesicles from focal segmental glomerulosclerosis pediatric patients induce STAT3 activation and mesangial cell proliferation.

Naile T PekkucuksenLauren P LiuRasha AlyLawrence R ShoemakerAbdel A Alli

Published in: PloS one (2022)

Our data demonstrate that EVs from FSGS patients stimulate mesangial cell proliferation in association with upregulation of the phospho-STAT-3 pathway. Additional studies are planned to identify the molecular cargo within the EVs from FSGS patients that contribute to the pathogenesis of FSGS.

Keyphrases

cell proliferation
end stage renal disease
ejection fraction
chronic kidney disease
newly diagnosed
prognostic factors
cell cycle
poor prognosis
signaling pathway
endothelial cells
patient reported outcomes
diabetic nephropathy
high glucose
single molecule