Alcohol-Induced Interleukin-17 Expression Causes Murine Lung Fibroblast-to-Myofibroblast Transdifferentiation via Thy-1 Down-Regulation.
Wendy A NeveuBashar S StaitiehStephen T MillsDavid M GuidotViranuj SueblinvongPublished in: Alcoholism, clinical and experimental research (2019)
Alcohol exposure skews T cells toward a Th17 immune response that in turn primes the lung for fibroproliferative disrepair through loss of Thy-1 expression and induction of myofibroblast differentiation. These effects suggest that IL-17 and TGFβ1 contribute to fibroproliferative disrepair in the lung and targeting these proteins could limit morbidity and mortality following lung injury in alcoholic individuals.
Keyphrases
- poor prognosis
- transforming growth factor
- immune response
- alcohol consumption
- high glucose
- liver injury
- cancer therapy
- long non coding rna
- drug induced
- diabetic rats
- pulmonary fibrosis
- fluorescent probe
- endothelial cells
- sensitive detection
- signaling pathway
- oxidative stress
- toll like receptor
- living cells
- quantum dots
- wound healing
- single molecule