Effects of supplementation with nondigestible carbohydrates on fecal calprotectin and on epigenetic regulation of SFRP1 expression in the large-bowel mucosa of healthy individuals.
Fiona C MalcomsonNaomi D WillisIain McCallumLong XieIdoia Ibero-BaraibarWing C LeungSeamus KellyD Michael BradburnNigel J BelshawIan T JohnsonJohn Cummings MathersPublished in: The American journal of clinical nutrition (2017)
RS and polydextrose supplementation did not affect fecal calprotectin concentrations. Downregulation of SFRP1 with RS and polydextrose could result in increased Wnt pathway activity. However, effects on Wnt pathway activity and downstream functional effects in the healthy large-bowel mucosa remain to be investigated. The DISC Study was registered at clinicaltrials.gov as NCT01214681.