Adoptive cell therapy of triple negative breast cancer with redirected cytokine-induced killer cells.
Roberta SommaggioElisa CappuzzelloAnna Dalla PietàAnna TosiPierangela PalmeriniDebora CarpaneseLorenzo NicolèAntonio RosatoPublished in: Oncoimmunology (2020)
ACT, Adoptive Cell Transfer; ADCC, Antibody-Dependent Cell-mediated Cytotoxicity; ADP, Adenosine diphosphate; BLI, Bioluminescence Imaging; CAR, Chimeric Antigen Receptor; CIK, Cytokine Induced Killer cells; CTX, Cetuximab; DMEM, Dulbecco's Modified Eagle Medium; EGFR, Human Epidermal Growth Factor 1; ER, Estrogen; FBS, Fetal Bovine Serum; FFPE, Formalin-Fixed Paraffin-Embedded; GMP, Good Manufacturing Practices; GVHD, Graft Versus Host Disease; HER2, Human Epidermal Growth Factor 2; HRP, Horseradish Peroxidase; IFN-γ, Interferon-γ; IHC, Immunohistochemistry; IL-2, Interleukin-2; ISO, Irrelevant antibody; i.t., intratumoral; i.v., intravenous, mAbs, Monoclonal Antibodies; mIHC, Multiplex Fluorescence Immunohistochemistry; MHC, Major Histocompatibility Complex; NK, Natural Killer; NKG2D, Natural-Killer group 2 member D; NSG, NOD/SCID common γ chain knockout; PARP, Poly ADP-ribose polymerase; PBMCs, Peripheral Blood Mononuclear Cells; PBS, Phosphate-buffered saline; PDX, Patient-derived xenograft; PR, Progesterone; rhIFN-γ, Recombinant Human Interferon-γ; RPMI, Roswell Park Memorial Institute; STR, Short tandem Repeat; TCR, T Cell Receptor; TNBC, Triple Negative Breast Cancer; TSA, Tyramide Signal Amplification.
Keyphrases
- cell therapy
- growth factor
- endothelial cells
- induced apoptosis
- stem cells
- high glucose
- mesenchymal stem cells
- cell cycle arrest
- recombinant human
- dendritic cells
- nk cells
- small cell lung cancer
- diabetic rats
- estrogen receptor
- immune response
- primary care
- oxidative stress
- endoplasmic reticulum stress
- high resolution
- healthcare
- pluripotent stem cells
- cell death
- escherichia coli
- multidrug resistant
- squamous cell carcinoma
- single molecule
- single cell
- hydrogen peroxide
- high throughput
- protein kinase
- dna repair
- radiation therapy
- natural killer cells
- metastatic colorectal cancer
- label free
- acute lymphoblastic leukemia
- electron transfer