Basal expression of RAD51 foci predicts olaparib response in patient-derived ovarian cancer xenografts.

F GuffantiM F AlvisiA AnastasiaF RicciM ChiappaA Llop-GuevaraVioleta SerraR FruscioAndrea DegasperiS Nik-ZainalM R BaniM LupiaR GiavazziE RulliGiovanna Damia

Published in: British journal of cancer (2021)

The basal RAD51 foci score is a candidate predictive biomarker of olaparib response in OC patients as it can be easily translatable in a clinical setting. Moreover, the findings corroborate the importance of OC-PDXs as a reliable tool to identify and validate biomarkers of response to therapy.

Keyphrases

end stage renal disease
dna damage
newly diagnosed
ejection fraction
dna repair
poor prognosis
chronic kidney disease
prognostic factors
peritoneal dialysis
stem cells
mesenchymal stem cells
binding protein