Tryptophan 2,3-dioxygenase 2 plays a key role in regulating the activation of fibroblast-like synoviocytes in autoimmune arthritis.
Yan ChangPing HanYueye WangChengyan JiaBingjie ZhangYingjie ZhaoSusu LiSiyu LiXinwei WangXuezhi YangWei WeiPublished in: British journal of pharmacology (2022)
Our results suggest that elevated TDO2 expression may contribute to synovial inflammation and joint destruction during arthritis. Therefore, targeting TDO2 activity and the Kyn pathway of Trp degradation may represent a potential therapeutic strategy in RA.