Canalization of genome-wide transcriptional activity in Arabidopsis thaliana accessions by MET1-dependent CG methylation.

Thanvi SrikantWei YuanKenneth Wayne BerendzenAdrián Contreras-GarridoHajk-Georg DrostRebecca SchwabDetlef Weigel

Published in: Genome biology (2022)

Systematic analysis of MET1 requirement in different A. thaliana accessions reveals a dual role for CG methylation: for many genes, CG methylation appears to canalize expression levels, with methylation masking regulatory divergence. However, for a smaller subset of genes, CG methylation increases expression diversity beyond genetically encoded differences.

Keyphrases

genome wide
dna methylation
arabidopsis thaliana
poor prognosis
copy number
gene expression
transcription factor
tyrosine kinase
long non coding rna
binding protein
oxidative stress
heat shock