Downregulation of androgen receptors by NaAsO2 via inhibition of AKT-NF-κB and HSP90 in castration resistant prostate cancer.
Yunlim KimSang Eun ParkJeong-Weon MoonBong-Min KimHa-Gyeong KimIn Gab JeongSangjun YooJae Beom AhnDalsan YouJhang Ho PakSujong KimJung Jin HwangChoung-Soo KimPublished in: The Prostate (2017)
Here, we show that NaAsO2 disrupts AR signaling at multiple levels by affecting AR expression, stability, and degradation in primary tumor cell cultures from prostate cancer patients as well as CRPC cell lines. These results suggest that NaAsO2 could be a novel therapeutics for prostate cancer.
Keyphrases
- prostate cancer
- signaling pathway
- cell proliferation
- radical prostatectomy
- poor prognosis
- pi k akt
- single cell
- heat shock protein
- cell therapy
- small molecule
- lps induced
- heat stress
- oxidative stress
- binding protein
- long non coding rna
- mesenchymal stem cells
- immune response
- benign prostatic hyperplasia
- toll like receptor