The transcriptional landscape and diagnostic potential of long non-coding RNAs in esophageal squamous cell carcinoma.
Meng ZhouSiqi BaoTongyang GongQiang WangJie SunJiaqi LiMinyi LuWanyuan SunJianzhong SuHongyan ChenZhihua LiuPublished in: Nature communications (2023)
Esophageal squamous cell carcinoma (ESCC) is a deadly cancer with no clinically relevant biomarkers for early detection. Here, we comprehensively characterized the transcriptional landscape of long non-coding RNAs (lncRNAs) in paired tumor and normal tissue specimens from 93 ESCC patients, and identified six key malignancy-specific lncRNAs that were integrated into a Multi-LncRNA Malignancy Risk Probability model (MLMRPscore). The MLMRPscore performed robustly in distinguishing ESCC from normal controls in multiple in-house and external multicenter validation cohorts, including early-stage I/II cancer. In addition, five candidate lncRNAs were confirmed to have non-invasive diagnostic potential in our institute plasma cohort, showing superior or comparable diagnostic accuracy to current clinical serological markers. Overall, this study highlights the profound and robust dysregulation of lncRNAs in ESCC and demonstrates the potential of lncRNAs as non-invasive biomarkers for the early detection of ESCC.
Keyphrases
- long non coding rna
- poor prognosis
- network analysis
- papillary thyroid
- genome wide analysis
- genome wide identification
- gene expression
- transcription factor
- squamous cell
- end stage renal disease
- newly diagnosed
- single cell
- clinical trial
- squamous cell carcinoma
- patient reported outcomes
- prognostic factors
- peritoneal dialysis
- lymph node metastasis
- childhood cancer
- heat stress
- double blind