Distinct associations of NEDD4L expression with genetic abnormalities and prognosis in acute myeloid leukemia.

Ming-Qiang ChuLiu-Chao ZhangQian YuanTing-Juan ZhangJing-Dong Zhou

Published in: Cancer cell international (2021)

Our findings indicated that NEDD4L underexpression, as a frequent event in AML, was associated with genetic abnormalities and prognosis in AML. Moreover, NEDD4L expression may be involved in leukemogenesis with potential therapeutic target value.

Keyphrases

poor prognosis
acute myeloid leukemia
genome wide
copy number
binding protein
allogeneic hematopoietic stem cell transplantation
long non coding rna
dna methylation
acute lymphoblastic leukemia