Kidney disease progression in pediatric and adult posterior urethral valves (PUV) patients.
Victoria W HuangMohga BehairyBenjamin AbelsonAlice CraneWei LiuLu WangKatherine M DellAudrey RheePublished in: Pediatric nephrology (Berlin, Germany) (2023)
PUV patients show progressive loss of kidney function well into adulthood. Proteinuria and recurrent UTIs are associated with faster progression, suggesting potential modifiable risk factors. This is the first study to report annualized eGFR decline rates in PUV patients, which could help inform the design of clinical trials of CKD therapies. A higher resolution version of the Graphical abstract is available as Supplementary information.
Keyphrases
- end stage renal disease
- chronic kidney disease
- ejection fraction
- newly diagnosed
- risk factors
- peritoneal dialysis
- healthcare
- prognostic factors
- multiple sclerosis
- patient reported outcomes
- randomized controlled trial
- heart failure
- aortic valve
- left ventricular
- young adults
- tyrosine kinase
- health information
- open label
- aortic stenosis
- transcatheter aortic valve replacement
- phase ii