Is the efficacy of antibiotic prophylaxis for surgical procedures decreasing? Systematic review and meta-analysis of randomized control trials.

Sumanth GandraAnna TrettGerardo Alvarez-UriaJoseph S SolomkinRamanan Laxminarayan

Published in: Infection control and hospital epidemiology (2018)

The efficacy of antibiotic prophylaxis agents in preventing SSIs following colorectal surgery has declined. Small number of RCTs and low infections rates limited our ability to assess true effect for simple appendectomy, cesarean section, or TRPB.

Keyphrases

open label
phase iii
randomized controlled trial
clinical trial
placebo controlled