Vitamin D Inhibits IL-6 Pro-Atherothrombotic Effects in Human Endothelial Cells: A Potential Mechanism for Protection against COVID-19 Infection?

Giovanni CimminoStefano ConteMariarosaria MorelloGrazia PellegrinoLaura MarraAndrea MorelloGiuseppe NicolettiGiuseppe De De RosaPaolo GolinoPlinio Cirillo

Published in: Journal of cardiovascular development and disease (2022)

IL-6 induces endothelial dysfunction with TF and CAMs expression via upregulation of ACE2r. VitD prevented these IL-6 deleterious effects. Thus, it might be speculated that this is one of the hypothetical mechanism(s) by which VitD exerts its beneficial effects in COVID-19 infection.

Keyphrases

endothelial cells
poor prognosis
cell proliferation
high glucose
angiotensin ii
signaling pathway
long non coding rna
risk assessment