Photoinduced Three-Component Carboarylation of Unactivated Alkenes with Protic C(sp³)-H Feedstocks.

A general and mild strategy involving three-component carboarylation of unactivated alkenes with protic C(sp³)-H feedstocks via photoredox catalysis was reported. This catalytic system is compatible with a broad range of unactivated alkenes, cyano-substituted arenes, and diverse protic C(sp³)-H feedstocks. The synthetic value of this protocol was demonstrated by the late-stage functionalization of complex molecules and the synthesis of the antiallergies including pheniramine, chlorpheniramine, and brompheniramine.