Myc manipulates the miRNA content and biologic functions of small cell lung cancer cell-derived small extracellular vesicles.

Published in: Molecular biology reports (2022)

Small extracellular vesicles and MYC are essential targets for therapeutic strategy in SCLC. Our study revealed that the expression level of MYC can affect the function of sEVs and encapsulate the miRNA composition in SCLC. Besides, small extracellular vesicles derived from SCLC cells can modulate normal lung cells.

Keyphrases

induced apoptosis
small cell lung cancer
cell cycle arrest
transcription factor
rheumatoid arthritis
poor prognosis
endoplasmic reticulum stress
oxidative stress
signaling pathway
single cell
binding protein