Login / Signup

Efficacy of BAFF inhibition and B-cell depletion in non-obese diabetic mice as a spontaneous model for Sjögren's disease.

Renaud FeltenAnne-Perrine ForayPascal SchneiderCindy MarquetCoralie PecquetFanny MonneauxHélène DumortierJean SibiliaFabrice ValetteLucienne ChatenoudJacques-Eric Gottenberg
Published in: RMD open (2024)
A monoclonal antibody blocking BAFF and depleting B cells had therapeutic effectiveness in the NOD mouse model of SjD. The increase in regulatory T-lymphocyte populations might underlie the efficacy of this treatment.
Keyphrases
  • monoclonal antibody
  • mouse model
  • randomized controlled trial
  • adipose tissue
  • systematic review
  • metabolic syndrome
  • weight loss
  • transcription factor
  • bariatric surgery
  • combination therapy
  • smoking cessation