Proinflammatory macrophage activation by the polysialic acid-Siglec-16 axis is linked to increased survival of glioblastoma patients.

Hauke Thiesler Lina Gretenkort Leonie Hoffmeister Iris Albers Luisa Ohlmeier Iris Röckle Andrea L Verhagen Rouzbeh Banan Nora Köpcke Nicole Krönke Friedrich Feuerhake Felix Behling Alonso Barrantes-Freer Dorothee Mielke Veit Rohde Bujung Hong Ajit Varki Kerstin Schwabe Joachim K Krauss Christine Stadelmann Christian Hartmann Herbert Hildebrandt

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)

Collectively, these results strongly suggest that proinflammatory TAM activation causes the better outcome in glioblastoma patients with a functional polySia-Siglec-16 axis.

Keyphrases

end stage renal disease
ejection fraction
chronic kidney disease
newly diagnosed
prognostic factors
peritoneal dialysis
adipose tissue
patient reported
free survival