Ajit Varki

ORCID

Publication Activity (10 Years)

Years Active: 1999-2023
Publications (10 Years): 24

Top Venues

Proceedings of the National Academy of Sciences of the United States of America

FASEB bioAdvances

Nature microbiology

Journal of immunology (Baltimore, Md. : 1950)

National Heart Lung and Blood Institute Consortium

This page only lists publications with an associated author ORCID identifier.

Affiliation History

National Heart Lung and Blood Institute Consortium

United States

National Coordinator :: Career Development in Glycosciences

Salk Institute for Biological Studies

United States

Adjunct Professor

Salk Center for Academic Research and Training in Anthropogeny (CARTA)

United States

Executive Co-Director

University of California San Diego Glycobiology Research and Training Center

United States

Co-Director

University of California San Diego School of Medicine

United States

Distinguished Professor :: Medicine and Cellular & Molecular Medicine

Publications

Hauke Thiesler, Lina Gretenkort, Leonie Hoffmeister, Iris Albers, Luisa Ohlmeier, Iris Röckle, Andrea L Verhagen, Rouzbeh Banan, Nora Köpcke, Nicole Krönke, Friedrich Feuerhake, Felix Behling, Alonso Barrantes-Freer, Dorothee Mielke, Veit Rohde, Bujung Hong, Ajit Varki, Kerstin Schwabe, Joachim K Krauss, Christine Stadelmann, Christian Hartmann, Herbert Hildebrandt
Proinflammatory macrophage activation by the polysialic acid-Siglec-16 axis is linked to increased survival of glioblastoma patients. Clinical cancer research : an official journal of the American Association for Cancer Research (2023)
Sudeshna Saha, Naazneen Khan, Troy Comi, Andrea Verhagen, Aniruddha Sasmal, Sandra Diaz, Hai Yu, Xi Chen, Joshua M Akey, Martin Frank, Pascal Gagneux, Ajit Varki
Evolution of Human-Specific Alleles Protecting Cognitive Function of Grandmothers. Molecular biology and evolution 39 (8) (2022)
Lisa Oh, Yang Ji, Wanqing Li, Ajit Varki, Xi Chen, Lee-Ping Wang
O -Acetyl Migration within the Sialic Acid Side Chain: A Mechanistic Study Using the Ab Initio Nanoreactor. Biochemistry 61 (18) (2022)
Shoib S Siddiqui, Michael Vaill, Ajit Varki
Ongoing selection for a uniquely human null allele of SIGLEC12 in world-wide populations may protect against the risk of advanced carcinomas. FASEB bioAdvances 3 (4) (2021)
Kunio Kawanishi, Joanna K Coker, Kaare V Grunddal, Chirag Dhar, Jason Hsiao, Karsten Zengler, Nissi Varki, Ajit Varki, Philip L S M Gordts
Dietary Neu5Ac Intervention Protects Against Atherosclerosis Associated With Human-Like Neu5Gc Loss-Brief Report. Arteriosclerosis, thrombosis, and vascular biology 41 (11) (2021)
Shoib S Siddiqui, Chirag Dhar, Venkatasubramaniam Sundaramurthy, Aniruddha Sasmal, Hai Yu, Esther Bandala-Sanchez, Miaomiao Li, Xiaoxiao Zhang, Xi Chen, Leonard C Harrison, Ding Xu, Ajit Varki
Sialoglycan recognition is a common connection linking acidosis, zinc, and HMGB1 in sepsis. Proceedings of the National Academy of Sciences of the United States of America 118 (10) (2021)
Sudeshna Saha, Alison Coady, Aniruddha Sasmal, Kunio Kawanishi, Biswa Choudhury, Hai Yu, Ricardo U Sorensen, Jaime Inostroza, Ian C Schoenhofen, Xi Chen, Anja Münster-Kühnel, Chihiro Sato, Ken Kitajima, Sanjay Ram, Victor Nizet, Ajit Varki
Exploring the Impact of Ketodeoxynonulosonic Acid in Host-Pathogen Interactions Using Uptake and Surface Display by Nontypeable Haemophilus influenzae. mBio 12 (1) (2021)
Sunita Gulati, Ian C Schoenhofen, Theresa Lindhout-Djukic, Melissa J Schur, Corinna S Landig, Sudeshna Saha, Lingquan Deng, Lisa A Lewis, Bo Zheng, Ajit Varki, Sanjay Ram
Therapeutic CMP-Nonulosonates against Multidrug-Resistant Neisseria gonorrhoeae. Journal of immunology (Baltimore, Md. : 1950) 204 (12) (2020)
Shoib Sarwar Siddiqui, Michael Vaill, Raymond Do, Naazneen Khan, Andrea L Verhagen, Wu Zhang, Heinz-Josef Lenz, Teresa L Johnson-Pais, Robin J Leach, Gary E Fraser, Charles Wang, Gen-Sheng Feng, Nissi Varki, Ajit Varki
Human-specific polymorphic pseudogenization of SIGLEC12 protects against advanced cancer progression. FASEB bioAdvances 3 (2) (2020)
Kunio Kawanishi, Chirag Dhar, Ajit Varki, Philip L S M Gordts
Reply to Soulillou et al.: Difficulties in extrapolating from animal models exemplify unusual human atherosclerosis susceptibility and mechanisms via CMAH loss. Proceedings of the National Academy of Sciences of the United States of America 117 (4) (2020)
Satoshi Uchiyama, Josh Sun, Kyoko Fukahori, Nao Ando, Mengyou Wu, Flavio Schwarz, Shoib S Siddiqui, Ajit Varki, Jamey D Marth, Victor Nizet
Dual actions of group B Streptococcus capsular sialic acid provide resistance to platelet-mediated antimicrobial killing. Proceedings of the National Academy of Sciences of the United States of America 116 (15) (2019)
Corinna S Landig, Ashley Hazel, Benjamin P Kellman, Jerry J Fong, Flavio Schwarz, Sarika Agarwal, Nissi Varki, Paola Massari, Nathan E Lewis, Sanjay Ram, Ajit Varki
Evolution of the exclusively human pathogen Neisseria gonorrhoeae: Human-specific engagement of immunoregulatory Siglecs. Evolutionary applications 12 (2) (2019)
Kunio Kawanishi, Chirag Dhar, Raymond Do, Nissi Varki, Philip L S M Gordts, Ajit Varki
Human species-specific loss of CMP-N-acetylneuraminic acid hydroxylase enhances atherosclerosis via intrinsic and extrinsic mechanisms. Proceedings of the National Academy of Sciences of the United States of America 116 (32) (2019)
Sudeshna Saha, Shoib S Siddiqui, Naazneen Khan, Andrea Verhagen, Weiping Jiang, Stevan Springer, Pradipta Ghosh, Ajit Varki
Controversies about the subcellular localization and mechanisms of action of the Alzheimer's disease-protective CD33 splice variant. Acta neuropathologica 138 (4) (2019)
Livia S Zaramela, Cameron Martino, Frederico Alisson-Silva, Steven D Rees, Sandra L Diaz, Léa Chuzel, Mehul B Ganatra, Christopher H Taron, Patrick Secrest, Cristal Zuñiga, Jianbo Huang, Dionicio Siegel, Geoffrey Chang, Ajit Varki, Karsten Zengler
Gut bacteria responding to dietary change encode sialidases that exhibit preference for red meat-associated carbohydrates. Nature microbiology 4 (12) (2019)
Frederico Alisson-Silva, Janet Z Liu, Sandra L Diaz, Lingquan Deng, Mélanie G Gareau, Ronald Marchelletta, Xi Chen, Victor Nizet, Nissi Varki, Kirsteen N Browning, Ajit Varki
Human evolutionary loss of epithelial Neu5Gc expression and species-specific susceptibility to cholera. PLoS pathogens 14 (6) (2018)
Jonathan Okerblom, William Fletes, Hemal H Patel, Simon Schenk, Ajit Varki, Ellen C Breen
Human-like Cmah inactivation in mice increases running endurance and decreases muscle fatigability: implications for human evolution. Proceedings. Biological sciences 285 (1886) (2018)
Annie N Samraj, Kimberly A Bertrand, Robert Luben, Zahra Khedri, Hai Yu, Dzung Nguyen, Christopher J Gregg, Sandra L Diaz, Sherilyn Sawyer, Xi Chen, A Heather Eliassen, Vered Padler-Karavani, Kana Wu, Kay-Tee Khaw, Walter Willett, Ajit Varki
Polyclonal human antibodies against glycans bearing red meat-derived non-human sialic acid N-glycolylneuraminic acid are stable, reproducible, complex and vary between individuals: Total antibody levels are associated with colorectal cancer risk. PloS one 13 (6) (2018)
Kathryn A Patras, Alison Coady, Joshua Olson, Syed Raza Ali, Satish P RamachandraRao, Satish Kumar, Ajit Varki, Victor Nizet
Tamm-Horsfall glycoprotein engages human Siglec-9 to modulate neutrophil activation in the urinary tract. Immunology and cell biology 95 (10) (2017)
Jonathan J Okerblom, Flavio Schwarz, Josh Olson, William Fletes, Syed Raza Ali, Paul T Martin, Christopher K Glass, Victor Nizet, Ajit Varki
Loss of CMAH during Human Evolution Primed the Monocyte-Macrophage Lineage toward a More Inflammatory and Phagocytic State. Journal of immunology (Baltimore, Md. : 1950) 198 (6) (2017)
Xiang Gao, Lingquan Deng, Gabrielle Stack, Hai Yu, Xi Chen, Yuko Naito-Matsui, Ajit Varki, Jorge E Galán
Evolution of host adaptation in the Salmonella typhoid toxin. Nature microbiology 2 (12) (2017)
C David Owen, Louise E Tailford, Serena Monaco, Tanja Šuligoj, Laura Vaux, Romane Lallement, Zahra Khedri, Hai Yu, Karine Lecointe, John Walshaw, Sandra Tribolo, Marc Horrex, Andrew Bell, Xi Chen, Gary L Taylor, Ajit Varki, Jesus Angulo, Nathalie Juge
Unravelling the specificity and mechanism of sialic acid recognition by the gut symbiont Ruminococcus gnavus. Nature communications 8 (1) (2017)
Flavio Schwarz, Corinna S Landig, Shoib Siddiqui, Ismael Secundino, Joshua Olson, Nissi Varki, Victor Nizet, Ajit Varki
Paired Siglec receptors generate opposite inflammatory responses to a human-specific pathogen. The EMBO journal 36 (6) (2017)
Jonathan J Okerblom, Ajit Varki
Biochemical, Cellular, Physiological, and Pathological Consequences of Human Loss of N-Glycolylneuraminic Acid. Chembiochem : a European journal of chemical biology 18 (13) (2017)
Ajit Varki
The 1999 ASCI Presidential Address: Executive Summary of the Nerflex Commission Report The Journal of clinical investigation 104 (12) (1999)

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Publication Activity (10 Years)

Top Topics

Top Venues

Ajit Varki