Targeting Plk1 Sensitizes Pancreatic Cancer to Immune Checkpoint Therapy.

Zhuang-Zhuang Zhang Lijun Cheng Jie Li Qi Qiao Anju Karki Derek B Allison Nuha Shaker Kunyu Li Sagar M Utturkar Nadia Atallah Lanman Xiongjian Rao Piotr Rychahou Daheng He Stephen F Konieczny Chi Wang Qing Shao B Mark Evers Xiaoqi Liu

Published in: Cancer research (2022)

Inhibition of Plk1 induces upregulation of PD-L1 expression in pancreatic ductal adenocarcinoma, stimulating antitumor immunity and sensitizing tumors to immunotherapy.

Keyphrases

poor prognosis
cell proliferation
cancer therapy
signaling pathway
induced apoptosis
bone marrow
long non coding rna
mesenchymal stem cells