Theranostic application of 64Cu/177Lu-labeled anti-Trop2 monoclonal antibody in pancreatic cancer tumor models.

Cuicui LiJun LiuXu YangQi YangWenpeng HuangMingyu ZhangDandan ZhouRong WangJianhua GongQingfang MiaoLei KangJi-Gang Yang

Published in: European journal of nuclear medicine and molecular imaging (2022)

This study demonstrated that 64Cu/177Lu-labeled hIMB1636 could noninvasively evaluate the expression level of Trop2 and inhibit the Trop2-overexpressed tumor growth in pancreatic cancer tumor models. Further clinical evaluation and translation of Trop2-targeted drug may be of great help in the stratification and management of pancreatic cancer patients.

Keyphrases

monoclonal antibody
clinical evaluation
pet imaging
poor prognosis
cancer therapy
fluorescence imaging
drug delivery