Adipocyte hypertrophy in mesenchymal stem cells from infants of mothers with obesity.

Madeline Rose KeleherShreya ShubhangiAsya BrownAllison M DuensingManoel E LixandrãoKathleen M GavinHarry A SmithKaterina J KechrisIvana V YangDana DabeleaKristen E Boyle

Published in: Obesity (Silver Spring, Md.) (2023)

Ob-MSCs have an intrinsic propensity for adipocyte hypertrophy and reduced hyperplasia during adipogenesis in vitro, perhaps linked to greater Zfp423 content and changes in cell cycle pathway gene expression.

Keyphrases

cell cycle
insulin resistance
mesenchymal stem cells
gene expression
high fat diet induced
adipose tissue
umbilical cord
cell proliferation
metabolic syndrome
fatty acid
skeletal muscle
type diabetes
bone marrow
dna methylation
weight loss
cell therapy
body mass index