Randomised trial of acid inhibition by vonoprazan 10/20 mg once daily vs rabeprazole 10/20 mg twice daily in healthy Japanese volunteers (SAMURAI pH study).

Toshihisa Takeuchi Takahisa Furuta Yasuhiro Fujiwara Mitsushige SugimotoKunio KasugaiMotoyasu KusanoHiroyuki OkadaTakahiro SuzukiTomohiro HiguchiTakuma KagamiTakahiro UotaniMihoko YamadeAkinari Sawada Fumio TanakaSatoshi HaradaKazuhiro OtaYuichi KojimaMasaki MurataYasuhiro TamuraYasushi FunakiOsamu KawamuraYuki OkamotoKazuma FujimotoKazuhide Higuchi

Published in: Alimentary pharmacology & therapeutics (2020)

Compared with 2-4 times the standard daily dose of R, V20 exerts a more potent and durable acid-inhibitory effect. Trial identifier: UMIN000022198 (www.umin.ac.jp/ctr/index.htm).

Keyphrases

physical activity
study protocol
helicobacter pylori
clinical trial
randomized controlled trial
open label
endoscopic submucosal dissection
gastroesophageal reflux disease