Safety of direct-acting oral anticoagulant (DOAC) prescribing: OpenSAFELY-TPP analysis of 20.5 million adults' electronic health records.
Karen HomanRachel SeeleyLouis FisherCarol A RobertsSajida KhatriKatie SmithTony JamiesonVictoria SpeedSebastian BaconAmir MehrkarBrian MackennaBen GoldacrePublished in: BJGP open (2024)
CrCl is not recorded for a substantial number of patients on DOACs. We recommend that national organisations tasked with safety, collectively update guidance on the appropriate weight to use in the Cockcroft-Gault equation, clarify that CrCl is not equivalent to eGFR and work with GP clinical system suppliers to standardise the calculation of CrCl in the EHR.
Keyphrases
- electronic health record
- end stage renal disease
- small cell lung cancer
- direct oral anticoagulants
- ejection fraction
- primary care
- newly diagnosed
- chronic kidney disease
- clinical decision support
- peritoneal dialysis
- body mass index
- atrial fibrillation
- prognostic factors
- emergency department
- epidermal growth factor receptor
- weight gain
- patient reported outcomes
- patient reported
- drug induced