Vitexin and Isovitexin Act through Inhibition of Insulin Receptor to Promote Longevity and Fitness in Caenorhabditis elegans.

Mingfang TaoRong LiZhuo ZhangTing WuTingting XuDaniel ZogonaYuting HuangSiyi PanXiaoyun Xu

Published in: Molecular nutrition & food research (2022)

Vitexin and isovitexin may inhibit IIS pathway by occupying adenosine-triphosphate binding site pocket of IGFR, subsequently decreasing IGFR expression, thereby promoting longevity and fitness.

Keyphrases

body composition
physical activity
poor prognosis
type diabetes
drosophila melanogaster
binding protein
long non coding rna
adipose tissue