A genome-wide cross-trait analysis identifies shared loci and causal relationships of type 2 diabetes and glycaemic traits with polycystic ovary syndrome.

Qianwen Liu Bowen Tang Zhaozhong Zhu Peter Kraft Qiaolin Deng Elisabet Stener-Victorin Xia Jiang

Published in: Diabetologia (2022)

We found a genetic link underlying type 2 diabetes, glycaemic traits and PCOS, driven by both biological pleiotropy and causal mediation, some of which is independent of BMI. Our findings highlight the importance of controlling fasting insulin levels to mitigate the risk of PCOS, as well as screening for and long-term monitoring of type 2 diabetes in all women with PCOS, irrespective of BMI.

Keyphrases

genome wide
type diabetes
polycystic ovary syndrome
insulin resistance
dna methylation
glycemic control
body mass index
copy number
blood glucose
cardiovascular disease
weight gain
adipose tissue
gene expression
social support
blood pressure
skeletal muscle