Early In-Bed Cycle Ergometry in Mechanically Ventilated Patients.
Michelle E KhoSusan BerneyAmy M PastvaLaurel KellyJulie C ReidKaren E A BurnsAndrew J SeelyFrédérick D'AragonBram RochwergIan BallAlison E Fox-RobichaudTim KarachiFrancois LamontagnePatrick M ArchambaultJennifer L TsangErick H DuanJohn MuscedereAvelino C VercelesKarim SerriShane W EnglishBrenda K ReeveSangeeta MehtaJill C RudkowskiDiane Heels-AnsdellHeather K O'GradyGeoff StrongKristy ObrovacDaana AjamiLaura CamposilvanJean-Eric TarrideLehana ThabaneMargaret S HerridgeDeborah J CookPublished in: NEJM evidence (2024)
Among adults receiving mechanical ventilation in the ICU, adding early in-bed Cycling to usual physiotherapy did not improve physical function at 3 days after discharge from the ICU compared with Usual physiotherapy alone. Cycling did not cause any serious adverse events. (Funded by the Canadian Institutes of Health Research and others; ClinicalTrials.gov numbers, NCT03471247 [full randomized clinical trial] and NCT02377830 [CYCLE Vanguard 46-patient internal pilot].).
Keyphrases
- mechanical ventilation
- intensive care unit
- acute respiratory distress syndrome
- ejection fraction
- end stage renal disease
- newly diagnosed
- respiratory failure
- extracorporeal membrane oxygenation
- high intensity
- prognostic factors
- randomized controlled trial
- clinical trial
- patient reported outcomes
- study protocol
- double blind