Haloperoxidase-mimicking CeO 2- x nanorods for the deactivation of human coronavirus OC43.

Jiayan Lang Xiaojing Ma Pengyu ChenMax D SerotaNicole M AndreGary R WhittakerRong Yang

Published in: Nanoscale (2022)

Despite the excellent antibacterial and antifouling effects of haloperoxidase (HPO)-mimicking CeO 2- x nanorods, their antiviral efficiency has not been explored. Herein, we designed and synthesized CeO 2- x nanorods with varying aspect ratios via the hydrothermal method. CeO 2- x nanorods catalysed the oxidative bromination of Br - and H 2 O 2 to HOBr, the kinetics of which were studied systematically using a phenol red assay. The CeO 2- x nanorods with the optimized aspect ratio ( i.e. , 4.5) demonstrated strong antiviral efficacies against the human coronavirus OC43, with no visible toxicity to the HCT-8 host cells.

Keyphrases

reduced graphene oxide
endothelial cells
sars cov
induced pluripotent stem cells
induced apoptosis
cell cycle arrest
pluripotent stem cells
gold nanoparticles
oxidative stress
high throughput
signaling pathway
risk assessment
respiratory syndrome coronavirus
silver nanoparticles
oxide nanoparticles
wound healing