The Role of Antioxidants Supplementation in Clinical Practice: Focus on Cardiovascular Risk Factors.
Vittoria CammisottoCristina NocellaSimona BartimocciaValerio SanguigniDavide FrancomanoSebastiano SciarrettaDaniele PastoriMariangela PeruzziElena CavarrettaAlessandra D'AmicoValentina CastellaniGiacomo FratiRoberto CarnevaleSMiLe GroupPublished in: Antioxidants (Basel, Switzerland) (2021)
Oxidative stress may be defined as an imbalance between reactive oxygen species (ROS) and the antioxidant system to counteract or detoxify these potentially damaging molecules. This phenomenon is a common feature of many human disorders, such as cardiovascular disease. Many of the risk factors, including smoking, hypertension, hypercholesterolemia, diabetes, and obesity, are associated with an increased risk of developing cardiovascular disease, involving an elevated oxidative stress burden (either due to enhanced ROS production or decreased antioxidant protection). There are many therapeutic options to treat oxidative stress-associated cardiovascular diseases. Numerous studies have focused on the utility of antioxidant supplementation. However, whether antioxidant supplementation has any preventive and/or therapeutic value in cardiovascular pathology is still a matter of debate. In this review, we provide a detailed description of oxidative stress biomarkers in several cardiovascular risk factors. We also discuss the clinical implications of the supplementation with several classes of antioxidants, and their potential role for protecting against cardiovascular risk factors.
Keyphrases
- cardiovascular risk factors
- oxidative stress
- cardiovascular disease
- dna damage
- reactive oxygen species
- metabolic syndrome
- diabetic rats
- risk factors
- ischemia reperfusion injury
- cardiovascular events
- type diabetes
- induced apoptosis
- clinical practice
- blood pressure
- endothelial cells
- insulin resistance
- anti inflammatory
- machine learning
- weight loss
- signaling pathway
- deep learning
- weight gain
- body mass index
- case control
- induced pluripotent stem cells
- pluripotent stem cells