Predominant expression of Alzheimer's disease-associated BIN1 in mature oligodendrocytes and localization to white matter tracts.
Pierre De RossiVirginie Buggia-PrévotBenjamin L L ClaytonJared B VasquezCarson van SanfordRobert J AndrewRuben LesnickAlexandra BottéCarole DeytsSomeya SalemEshaan RaoRichard C RiceAngèle ParentSatyabrata KarBrian PopkoPeter PytelSteven EstusGopal ThinakaranPublished in: Molecular neurodegeneration (2016)
Our study provides new insights into the brain distribution and cellular expression of an important risk factor associated with late-onset AD. We propose that efforts to define how genetic variants in BIN1 elevate the risk for AD would behoove to consider BIN1 function in the context of its main expression in mature oligodendrocytes and the potential for a role of BIN1 in the membrane remodeling that accompanies the process of myelination.