The Influence of the BDNF Val66Met Polymorphism on the Association of Regular Physical Activity With Cognition Among Individuals With Diabetes.
Tingting LiuMcKenzie D CanonLuqi ShenBenjamin A MarplesJoseph P ColtonWen-Juo LoMichelle GrayChangwei LiPublished in: Biological research for nursing (2020)
This study provided preliminary findings on how BDNF variants may modulate the exercise-induced cognitive benefits among mid-aged and older adults with diabetes. Given the limitations of the current study, it is necessary for randomized controlled trials to stratify by BDNF genotypes to more conclusively determine whether Met carriers benefit more from increased physical activity. In addition, future research is needed to examine how the interplay of BDNF Val66Met variants, DNA methylation, and physical activity may have an impact on cognitive function among adults with diabetes.
Keyphrases
- physical activity
- type diabetes
- dna methylation
- cardiovascular disease
- glycemic control
- stress induced
- tyrosine kinase
- copy number
- body mass index
- randomized controlled trial
- gene expression
- systematic review
- metabolic syndrome
- adipose tissue
- genome wide
- skeletal muscle
- mild cognitive impairment
- multiple sclerosis
- sleep quality
- insulin resistance