Long-term effects of pro-opiomelanocortin methylation induced in food-restricted dams on metabolic phenotypes in male rat offspring.
Sangmi LeeEun Jin KwonYoung-Ah YouJi Eun DuInho JoYoung Ju KimPublished in: Obstetrics & gynecology science (2020)
Our findings suggest that maternal food restriction during pregnancy influences the expression of hypothalamic appetite regulators via epigenetic changes, leading to the development of metabolic disorders in the offspring.
Keyphrases
- high fat diet
- dna methylation
- poor prognosis
- gene expression
- high glucose
- human health
- diabetic rats
- oxidative stress
- genome wide
- birth weight
- weight loss
- type diabetes
- anti inflammatory
- adipose tissue
- pregnant women
- insulin resistance
- pregnancy outcomes
- drug induced
- long non coding rna
- physical activity
- weight gain
- stress induced