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CRISPR Tackles Emerging Viral Pathogens.

Emily N KirbyByron ShuePaul Q ThomasMichael R Beard
Published in: Viruses (2021)
Understanding the dynamic relationship between viral pathogens and cellular host factors is critical to furthering our knowledge of viral replication, disease mechanisms and development of anti-viral therapeutics. CRISPR genome editing technology has enhanced this understanding, by allowing identification of pro-viral and anti-viral cellular host factors for a wide range of viruses, most recently the cause of the COVID-19 pandemic, SARS-CoV-2. This review will discuss how CRISPR knockout and CRISPR activation genome-wide screening methods are a robust tool to investigate the viral life cycle and how other class 2 CRISPR systems are being repurposed for diagnostics.
Keyphrases
  • genome editing
  • sars cov
  • crispr cas
  • genome wide
  • respiratory syndrome coronavirus
  • healthcare
  • life cycle
  • multidrug resistant
  • antimicrobial resistance