Increased expression of MUSASHI1 in epithelial breast cancer cells is due to down regulation of miR-125b.
Mahboobeh ForouzanfarLiana LachinaniKianoush DormianiMohammad Hossein Nasr-EsfahaniKamran GhaediPublished in: BMC molecular and cell biology (2021)
The results of luciferase reporter assay showed that MSI1 is a direct target for miR-125b in epithelial breast cancer cells. Moreover, higher amount of MSI1 in those cell lines seems due to the reduced amount of miR-125b, which is responsible for epithelial features of those kinds of cancer cells. Therefore, the modulation of miR-125b may be a potential approach to help to combat against epithelial breast tumors.