circKDM4C enhances bladder cancer invasion and metastasis through miR-200bc-3p/ZEB1 axis.
Xueyou MaYufan YingJiazhu SunHaiyun XieJiangfeng LiLiujia HeWeiyu WangShiming ChenHaixiang ShenJiahe YiJindan LuoXiao WangXiangyi ZhengBen LiuLiping XiePublished in: Cell death discovery (2021)
Circular RNAs (circRNAs) play essential roles in human bladder cancer (BCa) development, however, unusual expression patterns and functional dysfunction of circRNAs in BCa have not been evaluated. In this study, we validated that circKDM4C (hsa_circ_0001839), derived from the KDM4C gene, is elevated in BCa cell lines as well as tissues. Functionally, overexpression of circKDM4C significantly enhances, and silencing of circKDM4C suppresses migration and invasion capabilities of BCa cells. Mechanistically, circKDM4C can directly interact with miR-200b-3p and miR-200c-3p as a miRNA sponge, which enhances the expression of ZEB1 and promotes mesenchymal phenotype. Conclusively, our findings indicate that circKDM4C may act as a pro-oncogenic factor in BCa invasion and metastasis via the circKDM4C/miR-200bc-3p/ZEB1 axis, which is a potential biomarker or therapeutic target for bladder cancer.
Keyphrases
- long non coding rna
- poor prognosis
- cell proliferation
- epithelial mesenchymal transition
- long noncoding rna
- induced apoptosis
- endothelial cells
- cell migration
- transcription factor
- stem cells
- gene expression
- signaling pathway
- copy number
- oxidative stress
- binding protein
- bone marrow
- genome wide
- cell death
- genome wide analysis