Rescuing epileptic and behavioral alterations in a Dravet syndrome mouse model by inhibiting eukaryotic elongation factor 2 kinase (eEF2K).

Stefania BerettaLaura GrittiLuisa PonzoniPaolo ScalmaniMassimo MantegazzaMariaelvina SalaChiara VerpelliCarlo Sala

Published in: Molecular autism (2022)

Our data indicate that pharmacological inhibition of eEF2K could represent a novel therapeutic intervention for treating epilepsy and related comorbidities in the Dravet syndrome.

Keyphrases

mouse model
randomized controlled trial
case report
signaling pathway
electronic health record
tyrosine kinase
big data
protein kinase
artificial intelligence