Cardiovascular risk factors indirectly affect acute post-stroke cognition through stroke severity and prior cognitive impairment: a moderated mediation analysis.
Bogna A DrozdowskaEmma ElliottMartin Taylor-RowanRobert C ShawGillian CuthbertsonPeter LanghorneTerence J QuinnPublished in: Alzheimer's research & therapy (2020)
We have shown that relationships between cardiovascular risk factors and cognition are complex and simple multivariable models may be overly reductionist. Including direct and indirect effects of risk factors, we constructed a model that explained a substantial proportion of variation in cognitive test scores. Models that include multiple paths of influence and interactions could be used to create dementia prognostic tools for use in other healthcare settings.
Keyphrases
- cardiovascular risk factors
- cognitive impairment
- mild cognitive impairment
- risk factors
- healthcare
- cardiovascular disease
- metabolic syndrome
- liver failure
- white matter
- atrial fibrillation
- wastewater treatment
- respiratory failure
- social support
- type diabetes
- drug induced
- depressive symptoms
- multiple sclerosis
- brain injury
- social media
- blood brain barrier
- health insurance