Amplified Type I Interferon Response in Sjögren's Disease via Ectopic Toll-Like Receptor 7 Expression in Salivary Gland Epithelial Cells Induced by Lysosome-Associated Membrane Protein 3.

Hiroyuki Nakamura Tsutomu TanakaChangyu ZhengSandra A AfioneTatsuya AtsumiMasayuki NoguchiFabiola Reis OliveiraAna Carolina F MottaFernando ChahudEduardo Melani Rocha Blake M WarnerJohn A Chiorini

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2024)

Epithelial LAMP3 misexpression can be induced through enhanced type I IFN response in salivary glands. In addition, LAMP3 can promote type I IFN production via ectopic TLR-7 expression in salivary gland epithelial cells. This positive feedback loop can contribute to maintaining LAMP3 misexpression and amplifying type I IFN production in salivary glands, which plays an essential role in the pathophysiology of SjD.

Keyphrases

toll like receptor
immune response
dendritic cells
loop mediated isothermal amplification
poor prognosis
nuclear factor
inflammatory response
binding protein
high glucose
long non coding rna
transcription factor
diabetic rats
fluorescent probe
oxidative stress
living cells
quantum dots