Left Ventricular Thrombus Therapy With Direct Oral Anticoagulants Versus Vitamin K Antagonists: A Systematic Review and Meta-Analysis.
Carolina Vila Chã Vaz SaleiroJoão LopesDiana De CamposLuís PugaMarco CostaLino GonçalvesRogério TeixeiraPublished in: Journal of cardiovascular pharmacology and therapeutics (2020)
Our systematic review and meta-analysis suggests DOACs were as effective as VKAs for LVT resolution, with a similar risk of systemic embolism/stroke and clinically relevant bleeding. These results, obtained from observational studies, are not definitive and hence randomized controlled trials are needed. Nevertheless, our analysis identifies key experimental features required in future studies.
Keyphrases
- direct oral anticoagulants
- atrial fibrillation
- venous thromboembolism
- left ventricular
- left atrial
- heart failure
- randomized controlled trial
- catheter ablation
- percutaneous coronary intervention
- genome wide
- acute myocardial infarction
- mitral valve
- single molecule
- hypertrophic cardiomyopathy
- stem cells
- aortic stenosis
- cardiac resynchronization therapy
- case control
- transcatheter aortic valve replacement
- coronary artery disease
- systematic review
- cerebral ischemia