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Efficacy and safety of maintenance therapy with pamiparib versus placebo for advanced gastric cancer responding to first-line platinum-based chemotherapy: Phase 2 study results.

Fortunato CiardielloYung-Jue BangAndrés CervantesMikhail DvorkinCharles D LopezJean-Philippe MetgesAntonio Sánchez RuizMariona CalvoAndrew H StricklandGeorge KannourakisKei MuroHiasto KawakamiJia WeiChristophe BorgZhaoyin ZhuNeal GuptaRobert J PelhamLin Shen
Published in: Cancer medicine (2023)
Maintenance pamiparib did not meet statistical significance for superiority versus placebo for PFS, but was well tolerated with few treatment discontinuations; no unexpected safety signals were identified.
Keyphrases
  • double blind
  • placebo controlled
  • neoadjuvant chemotherapy
  • open label
  • phase iii
  • squamous cell carcinoma
  • locally advanced
  • randomized controlled trial
  • stem cells
  • clinical trial
  • radiation therapy
  • lymph node