A red wine intervention does not modify plasma trimethylamine N-oxide but is associated with broad shifts in the plasma metabolome and gut microbiota composition.

Elisa A Haas Mario J A Saad Andrey Santos Nicola Vitulo Wilson José Fernandes Lemos Aline Maria Araujo Martins Carolina R C Picossi Desidério Favarato Renato Simões GasparDaniéla O MagroPeter Libby Francisco R M Laurindo Protásio Lemos da Luznull null

Published in: The American journal of clinical nutrition (2022)

Modulation of the gut microbiota may contribute to the putative cardiovascular benefits of moderate RW consumption. The low intraindividual concordance of TMAO presents challenges regarding its role as a cardiovascular risk biomarker at the individual level. This study was registered at clinical trials.gov, NCT03232099.

Keyphrases

clinical trial
randomized controlled trial
high intensity
open label
phase iii