Nyuzenamides A and B: Bicyclic Peptides with Antifungal and Cytotoxic Activity from a Marine-Derived Streptomyces sp.
Md Rokon Ul KarimYasuko InTao ZhouEnjuro HarunariNaoya OkuYasuhiro IgarashiPublished in: Organic letters (2021)
Two bicyclic peptides, nyuzenamides A (1) and B (2), were discovered from Streptomyces isolated from suspended matter in deep sea water collected in the Sea of Japan. Their structures were determined through nuclear magnetic resonance and mass spectrometry analyses in combination with X-ray crystallography and the chiral-phase gas chromatography-mass spectrometry method to comprise ten amino acid residues containing four unusual amino acids along with aromatic acyl units. Both compounds displayed antifungal activity against pathogenic fungi and cytotoxicity against P388 murine leukemia cells.
Keyphrases
- amino acid
- gas chromatography mass spectrometry
- magnetic resonance
- high resolution
- mass spectrometry
- gas chromatography
- induced apoptosis
- capillary electrophoresis
- cell cycle arrest
- acute myeloid leukemia
- solid phase extraction
- liquid chromatography
- bone marrow
- high performance liquid chromatography
- fatty acid
- tandem mass spectrometry
- contrast enhanced
- signaling pathway
- cell death
- endoplasmic reticulum stress
- oxidative stress
- dual energy