Uncovering the signalling, structure and function of the 20-HETE-GPR75 pairing: Identifying the chemokine CCL5 as a negative regulator of GPR75.

Jonathan V PascaleEon Joo ParkAdeniyi Michael AdebesinJohn R FalckMichal Laniado SchwartzmanVictor Garcia

Published in: British journal of pharmacology (2021)

We have identified 20-HETE as a high-affinity ligand for GPR75 and CCL5 as a low-affinity negative regulator of GPR75, providing additional evidence for the deorphanization of GPR75 as a 20-HETE receptor.

Keyphrases

fatty acid
transcription factor
liver injury
liver fibrosis